Short Non Coding Rnas Play The Rna And Represses The...

Abstract: MicroRNAs are short non-coding RNAs play main role in human diseases; it deregulates the RNA and represses the translation process by controlling gene expression. Some deregulated miRNAs express deferentially such as mir-125b, mir-145, mir-155, and mir-21 leads for partition between cancer and normal tissues. miRNAs expression with particular cancer biopathologic features in breast, such as tumor stage, estrogen and progesterone receptor expression, vascular invasion, or proliferation index. Exiqon microarrays analysis revealed that the most of the miRNAs down regulated in hereditary breast cancer by comparing the normal and cancer tissues, and by using mechanism of tumor progression and also pathway enrichment analysis showed†¦show more content†¦Introduction: Mature miRNA binds to the target mRNA by base pairing and down regulates the expression by degrading mRNA or blocking translation. Mature miRNA are 19 to 25 nucleotides cleaved from Pre-miRNA contain 70 to 100-nucleotides in cytoplasm (Bartel DP 2004). miRNAs role in human cancer is occurred from deletion of 13q14 in human chronic lymphocytic leukemia (CLL) that contains mir-15a and mir-16-1 genes within the deletion region. These two genes were affected by chromosomal translocation and then down regulated in 50% to 60% of human CLL (Calin GA et al. 2002). Breast cancer (BR) is most common in woman, approximately one in forty women affected by breast cancer in very young (BCVY). This was occurred by HER2 over expression, lymph node invasion, an absence of hormone receptor (HR) expression, and larger and poorly differentiated tumors present (Anders CK et al. 2011). Molecular markers are identified by miRNA expression profiling regarding BR. Molecular markers, such as miR-21, miR-9, miR-205, miR-7, miR-200 family, miR-335 and miR-126, which associate with proliferative capacity, high metastatic, poor prognosis and large size of tumors (Shimono Y et al. 2009). In hereditary breast cancers, down regulated miRNAs are occurred by KRAS oncogene. Deregulation and down regulation of let-7 of some miRNAs in genomic regions leads to human cancer diseases. Initiation, metastasis,